Duke Researchers Find Crucial Link Between Gut Inflammation and Colon Cancer | News

Duke Researchers Find Crucial Link Between Gut Inflammation and Colon Cancer

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XILING SHEN, DUKE UNIVERSITY
  • Xiling Shen, Duke University
Biomedical engineers at Duke University have discovered why chronic stomach inflammation increases the likelihood of colon cancer by as much as 500 percent.

The most exciting aspect of the discovery is that the early warning it provides also points to a new way to fight the second deadliest form of cancer.

The study, "A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer," was published Thursday in the online journal Cell Stem Cell.

It's broken down here, in terms slightly more digestible by laypersons, in the blog Science 2.0:


Duke scientists grew two sets of cellular "miniguts" on culture dishes and stimulated them with inflammatory factors. The miniguts on the left are normal. But on the right, the deletion of a MicroRNA called miR-34a causes stem cells (green markers in the top right image and red markers in the bottom right image) to divide out of control. This causes the minigut to bloat into a cancerous sphere.



Xiling Shen, associate professor of biomedical engineering at Duke University and lead author of the study, explains that the origin of a microRNA called miR-34a that "gives cancer stem cells the odd ability to divide asymmetrically" had always been a mystery. So his team focused on it.

More, from Science 2.0:


To find out, Shen and his colleagues deleted miR-34a from the genetic code of some mice. But nothing happened.

"It really puzzled the scientific community," said Shen. "Usually if something is important and you delete it, it causes a problem."

In the latest study, however, the problem showed up when the mice's tissues became inflamed. Without any microRNA miR-34a, their stem cells quickly grew out of control and formed many tumor-like structures.

The conclusion is that miR-34a is "the good guy," that "shows up only when things go wrong, according to Shen.


With a test to look for elevated levels of miR-34a, researchers could create an early warning system to catch cancers in their youthful stages when they are much easier to cure. And as a possible treatment for late-stage cancer, researchers are trying to get the cancer cells to express miR-34a again. This would stop the tumor cells from gaining the flexibility to revert back to stem cells and allow doctors to wipe them out once and for all.


Once and for all. You gotta love the sound of that. 

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